An Iso (short for Isolation) is an offensive play where the team gives the ball to one player and clears out of his way. This player is “isolated” from everyone else, and is basically one-on-one against his opponent. It works well when there is a size/skill advantage in favor of the offensive player.
Iso means isolation. When a player has the ball in his hands and his teammates spread out, giving him room to take his defended one on one. Avery Johnson calls isolation plays all throughout the 4th quarter’s. It is easy to notice.